Leuppi JD, et al. JAMA. 2013 Jun 5;309(21):2223-31.
This multicenter, double blinded trial demonstrated non-inferiority of a 5-day course of 40mg prednisone versus a 14-day course of 40mg prednisone in the treatment of patients admitted to hospital for acute exacerbation of COPD (AECOPD). Although the patient population was not identical to the ED population, the group agrees that these results should encourage ED physicians to prescribe a 5 day course of prednisone for uncomplicated AECOPD. By: Dr. Christopher Mong (Presented April 2014)
Epi lesson: Non-inferiority Trials