Montalescot G, van 't Hof AW, Lapostolle F, et al. for the ATLANTIC Investigators. N Engl J Med.2014 Sep 11;371(11):1016-27.
This corporate-sponsored international, multicenter, RCT randomized 1,862 STEMI patients to receive ticagrelor prehospital vs in-hospital and found no difference in outcomes (70% or greater reduction of ST-segment elevation prior to PCI and/or a relatively good flow in the culprit artery (TIMI grade 3)); there was also no difference in morbidity and mortality at 30 days. These results should discourage EMS services from administering prehospital ticagrelor. By: Dr. Jaroslav Fabian (Presented March 2015)
Epi lesson: Concealment versus Blinding These clinical trial terms have different meanings but are often confused. Concealment refers to the processwhereby the treatment allocation is made unknown or concealed prior to patient randomization. This helps prevent selection bias by ensuring that health providers …