Motov S, Rockoff B, Cohen V, et al. Ann Emerg Med. 2015 Mar 26. pii: S0196-0644(15)00191-2.
This prospective, RCT found sub-dissociative ketamine (0.3mg/kg) and morphine (0.1mg/kg) were similarly effective at reducing moderate to severe pain using a visual analogue pain scale at 30 minutes (mean difference 0.2; 95% confidence interval 1.19 to 1.46; P=0.97), but with increased minor side effects in the ketamine group. JC attendees discussed the limitations of using a continuous variable as a primary outcome, likely making this an underpowered study. Additionally, JC attendees thought the significantly increased side effects and short duration of ketamine would limit implementation into clinical practice. By: Dr. Nathan Hecht (Presented May 2015)
Epi lesson: Sample Size in Clinical Trials All intervention studies should indicate how the sample size was estimated including the desired alpha error (usually 0.05), power…