Young P, Saxena M, Bellomo R, et al. N Engl J Med. 2015 Oct 5.
Abstract Link This multicentre, ICU RCT received a methodology score of 4/5 and 2/5 for usefulness. They concluded that early treatment of fever with acetaminophen in suspected or confirmed infection results in moderate reduction in temperature, but does not affect the number of ICU-free days which was a composite endpoint combining mortality and ICU length of stay. Also, there was no statistically significant difference between acetaminophen versus placebo with respect to 28d mortality, 90d mortality, or survival time to day 90. By: Dr. Gauri Ghate (Presented December 2015)
Epi Lesson: Adjustment of Confidence Intervals for Interim Analyses
Interim analyses are commonly planned in large studies. This can be useful, for example, to ensure patient safety (either by finding a significant benefit or harm early on), or as a cost saving measure by stopping the study early if…